An efficient green procedure for the synthesis of bis (indolyl) methanes in water
نویسنده
چکیده مقاله:
In this work, a green, simple and highly efficient procedure for the synthesis of bis(indolyl)methanes is described. The condensation of indoles with carbonyl compounds catalyzed by citric acid in water affords bis(indolyl)methanes in high yields and relatively short reaction times. The advantages of this method are using of water as a low cost solvent and efficient recyclability of the catalyst.
منابع مشابه
an efficient green procedure for the synthesis of bis (indolyl) methanes in water
in this work, a green, simple and highly efficient procedure for the synthesis of bis(indolyl)methanes is described. the condensation of indoles with carbonyl compounds catalyzed by citric acid in water affords bis(indolyl)methanes in high yields and relatively short reaction times. the advantages of this method are using of water as a low cost solvent and efficient recyclability of the catalyst.
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β-Cyclodextrin sulfuric acid as a green Lewis acid catalyst has been applied for the preparation of bis(indolyl)methanes, tris(indolyl)methanes and 3,3'-diindolyloxindole derivatives by the condensation of indoles with various carbonyl compounds in aqueous media with high to excellent yields.
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Bis(indolyl)methanes are important group of bioactive metabolites of terrestrial and marine regions. They were synthesized by different methods. Herein, a clean, one-pot synthesis of bis(indolyl)methane derivatives by cyclo-condensation reaction of indole and various aldehydes using Sulfonic acid functionalized silica (SiO2-Pr-SO3H) in aqueous media is reported. The advantages of this new metho...
متن کاملGreen synthesis of bis(indolyl)methanes in water using sulfonic acid functionalized silica (SiO2-Pr-SO3H)
Bis(indolyl)methanes are important group of bioactive metabolites of terrestrial and marine regions. They were synthesized by different methods. Herein, a clean, one-pot synthesis of bis(indolyl)methane derivatives by cyclo-condensation reaction of indole and various aldehydes using Sulfonic acid functionalized silica (SiO2-Pr-SO3H) in aqueous media is reported. The advantages of this new metho...
متن کاملCerium (IV) Triflate as a Catalyst for Efficient and Green Synthesis of Bis (Indolyl) Methanes in Water
Efficient synthesis of bis(indolyl)methanes by the reaction of indole with certain aldehydes and ketones in water afforded the corresponding bis(indolyl)methanes in excellent yields. This reaction has been carried out in the presence of 2 mol% of cerium(IV)triflate at room temperature.
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A novel synthetic methodology for the synthesis of Bis(indolyl)methanes by using catalytic amount of ferric triflate was described Introduction Bis(indolyl)methanes consists two substituted indole units in the molecule. Bis indole derivatives are reported to exhibit a wide spectrum of pharmacological activities such as cytotoxic, antitumor antimicrobial [1] and antiactivities. [2] For the past ...
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عنوان ژورنال
دوره 24 شماره 3
صفحات 205- 208
تاریخ انتشار 2013-09-01
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